Biology may not be so complex after all, physicist finds

Secondary Source Summary

ScienceDaily (2010-03-19) — Centuries ago, scientists began reducing the physics of the universe into key laws described by a handful of parameters. Such simple descriptions have remained elusive for complex biological systems — until now. A biophysicist has identified parameters for several biochemical networks that distill the entire behavior of these systems into simple equivalent dynamics. The discovery may hold the potential to streamline the development of drugs and diagnostic tools, by simplifying the research models.


Emory University (2010, March 19). Biology may not be so complex after all, physicist finds. ScienceDaily. Retrieved March 19, 2010, from /releases/2010/03/100301102757.htm

Primary Source Abstract

Biochemical processes typically involve huge numbers of individual reversible steps, each with its own dynamical rate constants. For example, kinetic proofreading processes rely upon numerous sequential reactions in order to guarantee the precise construction of specific macromolecules. In this work, we study the transient properties of such systems and fully characterize their first passage (completion) time distributions. In particular, we provide explicit expressions for the mean and the variance of the completion time for a kinetic proofreading process and computational analyses for more complicated biochemical systems. We find that, for a wide range of parameters, as the system size grows, the completion time behavior simplifies: it becomes either deterministic or exponentially distributed, with a very narrow transition between the two regimes. In both regimes, the dynamical complexity of the full system is trivial compared to its apparent structural complexity. Similar simplicity is likely to arise in the dynamics of many complex multistep biochemical processes. In particular, these findings suggest not only that one may not be able to understand individual elementary reactions from macroscopic observations, but also that such an understanding may be unnecessary.


Golan Bel, Brian Munsky, Ilya Nemenman. The simplicity of completion time distributions for common complex biochemical processes. Physical Biology, 2009; 7 (1): 016003 DOI: 10.1088/1478-3975/7/1/016003


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